Disclosure Document

Document date:  Fri 11 Jan 2002
Published:  Fri 11 Jan 2002 00:00:00
Document No:  185999
Document part:  C
Market Flag:  Y
Classification: 

ANTISENSE THERAPEUTICS LIMITED                2002-01-11  ASX-SIGNAL-G

HOMEX - Melbourne                                                     

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THE OFFER

This Prospectus provides information on Antisense's Offer to
Circadian and Syngene shareholders. Shareholders of Circadian and
Syngene (other than shareholders with registered addresses outside
Australia) may take up one option, at one cent, to take up one
unissued share in Antisense at 20 cents on or before 1 February 2007
for every Circadian and Syngene share held as at the Record Date
(namely 8 January 2002) (Option). Special arrangements for
shareholders of Circadian or Syngene with registered addresses
outside Australia are set out in section 1.6 below.

The cost of one cent per Option is payable in full on application,
Holdings of Circadian or Syngene shares on different registers (or
subregisters) will be aggregated for calculating offers. Offers of
Options are non-renounceable, so the rights may not be sold or
otherwise renounced or disposed of.

The maximum number of Options which may be issued under this Offer is
64,405,618. Details of how Circadian and Syngene shareholders can
take up options are set out section 1.3 below.

KEY DATES

Option acceptances close (except for member          15 February 2002
organisations)

Option acceptances from member organisations close   22 February 2002

Despatch date.                                       4 March 2002

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