Appendix 3B - Exercise of options

Document date:  Wed 18 Sep 2002
Published:  Wed 18 Sep 2002 00:00:00
Document No:  194992
Document part:  A
Market Flag:  N
Classification: 

ANTISENSE THERAPEUTICS LIMITED                2002-09-18  ASX-SIGNAL-G

HOMEX - Melbourne                                                     

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                             APPENDIX 3B
                        NEW ISSUE ANNOUNCEMENT

   APPLICATION FOR QUOTATION OF ADDITIONAL SECURITIES AND AGREEMENT

Information or documents not available now must be given to ASX as
soon as available.  Information and documents given to ASX become
ASX's property and may be made public.

Introduced 1/7/96. Origin Appendix 5. Amended 1/7/98, 1/9/99,
1/7/2000.

Name of Entity
Antisense Therapeutics Limited

ABN
41 095 060 745

We (the entity) give ASX the following information.


PART 1 - ALL ISSUES
You must complete the relevant sections (attach sheets if
there is not enough space).


 
1. Class of securities issued          Ordinary shares (ANP)
   or to be issued                                                  
 
2. Number of securities issued         3,500
   or to be issued (if known)                                       
   or maximum number which                                          
   may be issued                                                    

3. Principal terms of the securities   Fully paid ordinary shares
   (eg, if options, exercise price                                  
   and expiry date; if partly paid                                  
   securities, the amount                                           
   outstanding and due dates for                                    
   payment; if convertible securities,                              
   the conversion price and dates                                   
   for conversion)                                                  

4. Do the securities rank equally      Yes
   in all respects from the date                                    
   of allotment with an existing                                    
   class of quoted securities                                       

   If the additional securities        N/A
   do not rank equally, please                                      
   state:                                                           
   * the date from which they do                                    
   * the extent to which they                                       
     participate for the next                                       
     dividend, (in the case of                                      
     a trust, distribution) or                                      
     interest payment                                               
   * the extent to which they do                                    
     not rank equally, other than                                   
     in relation to the next                                        
     dividend, distribution or                                      
     interest payment                                               

5. Issue price or consideration        3,500 ordinary shares at
                                       $0.20 cents per share

6. Purpose of the issue (if            Exercise of 3,500 options at
   issued as consideration for         $0.20 cents per share
   the acquisition of assets,          (originally issued on
   clearly identify those              (26/02/2002 and expiring on
   assets)                             01/02/2007)

7. Dates of entering securities        3,000 shares on 11/06/2002
   into uncertified holdings             400 shares on 09/07/2002
   or despatch of certificates           100 shares on 18/07/2002
                                       
                                      NUMBER  CLASS
8. Number and class of all        70,441,002  Ordinary shares (ANP)
   securities quoted on           91,472,495  Options (ANPO)
   ASX (including the                                               
   securities in clause                                             
   2 if applicable)                                                 

                                      NUMBER  CLASS
9. Number and class of all        11,250,000  Restricted ordinary
   securities not quoted                      shares (ANPAI)
   on ASX (including the         133,312,508  Restricted ordinary
   securities in clause 2                     shares (ANPAK)
   if applicable)                 11,500,000  Restricted options
                                              expiring 31/07/2005
                                              exercisable at 20 cents
                                              (ANPAM)
                                  20,000,000  Restricted options
                                              expiring 30/11/2006
                                              exercisable at 20 cents
                                              (ANPAO)
                                   2,450,000  Options expiring
                                              31/07/2005 exercisable
                                              at 20 cents (ANPAQ)

10.Dividend policy (in the case        N/A
   of a trust, distribution                                         
   policy) on the increased                                         
   capital (interests)                                              

PART 2 - BONUS ISSUE OR PRO RATA ISSUE

Items 11 to 33 are Not Applicable

PART 3 - QUOTATION OF SECURITIES
You need only complete this section if you are applying for quotation
of securities

     
34. Type of securities (tick one)

    (a) X  Securities described in Part 1

    (b)    All other securities

Example: restricted securities at the end of the escrowed period, 
partly paid securities that become fully paid, employee incentive 
share securities when restriction ends, securities issued on expiry
or conversion of convertible securities

    Entities that have Ticked Box 34(a)

    Additional Securities Forming a New Class of Securities
    (If the additional securities do not form a new class, go to 43)

    Tick to indicate you are providing the information or documents

35.     If the securities are equity securities, the names of
        the 20 largest holders of the additional securities,
        and the number and percentage of additional securities
        held by those holders

36.     If the securities are equity securities, a distribution
        schedule of the additional securities setting out the 
        number of holders in the categories
         1 - 1,000
         1,001 - 5,000
         5,001 - 10,000
         10,001 - 100,000
         100,001 - and over

37.    A copy of any trust deed for the additional securities
(now go to 43)

    Entities that have Ticked Box 34 (b)

    Items 38 to 42 are Not Applicable

ALL ENTITIES

Fees

43. Payment method (tick one)

       Cheque attached

       Electronic payment made
       Note: Payment may be made electronically if Appendix 3B is 
             given to ASX electronically at the same time.
    
    X  Periodic payment as agreed with the home branch has been 
       arranged
       Note: Arrangements can be made for employee incentive 
             schemes that involve frequent issues of securities.

QUOTATION AGREEMENT

1.  Quotation of our additional securities is in ASX's absolute 
    discretion. ASX may quote the securities on any conditions it 
    decides.

2.  We warrant the following to ASX.

    *   The issue of the securities to be quoted complies with the
        law and is not for an illegal purpose.

    *   There is no reason why those securities should not be granted
        quotation.

    *   An offer of the securities for sale within 12 months after 
        their issue will not require disclosure under section 707(3)
        or section 1012C(6) of the Corporations Act.

    *   Section 724 or section 1016E of the Corporations Act does not
        apply to any applications received by us in relation to any 
        securities to be quoted and that no-one has any right to 
        return any securities to be quoted under sections 737, 738 or
        1016F of the Corporations Act at the time that we request that 
        the securities be quoted.

    *   We warrant that if confirmation is required under section 
        1017F of the Corporations Act in relation to the securities to 
        be quoted, it has been provided at the time that we request
        that the securities be quoted.

    *   If we are a trust, we warrant that no person has the right to 
        return the securities to be quoted under section 1019B of the 
        Corporations Act at the time that we request that the 
        securities be quoted.
        
3.  We will indemnify ASX to the fullest extent permitted by law in
    respect of any claim, action or expense arising from or connected
    with any breach of the warranties in this agreement.

4.  We give ASX the information and documents required by this form.
    If any information or document not available now, will give it to
    ASX before quotation of the securities begins. We acknowledge that
    ASX is relying on the information and documents. We warrant that
    they are (will be) true and complete.


N Korchev 
COMPANY SECRETARY
18/09/2002